Mesothelioma Treatment Options

Mesothelioma Treatment Options

Mesothelioma Treatment Options

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Mesothelioma Treatment Options

By: Thomas Xiao
Posted: Oct 19, 2009

Of late,there are severalnew mesotheliomatreatments;are beingdeveloped. Thisgive rise to new hopes for moremesotheliomatreatmentoptions;for victimsof thisdisease.

Research is mostly;revolvingaround developing new treatments;or improvingupon the past traditional treatments;. It is veryencouragingfor mesotheliomapatientsas new chemotherapyagentsand combinationsof agentshavebeen showingimprovedresults.

Photodynamic therapy(PDT) is one of the new mesotheliomatreatmentoptions;beinglooked into. It is basedon the theorythatsingle celled organisms die when exposed to certain frequencyof light. In order for thisto happenin thistreatment, certain photosensitivedrugs;are administeredintravenouslyintothe patient. Normally, overa few days, the drugwill zoom in and concentrate on the diseased cellsand destroy it. There are however,someside effects suchas skin sensitivity, nausea and vomiting.

Another treatmentoptionis Immunotherapy, whichis sometimesknown as biologicaltherapy.In thistreatmentmethod, the immunesystemof the patient\’s body is usedto treatand fight off the disease.When struck by mesothelioma, the patientsbody’sability to treatitself might be hampered due to the disease.

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The Immunotherapytreatmentwill then try to rejuvenatethe patients\’ immunesystemand thereby, improvingthe patientsnaturalimmunesystemwhichis the mosteffectiveway to combat any disease.Thistherapywill alsotry to repair the immunesystems;in areaswhere they are faulty. A naturally;occuring;substance called, Biological response modifiers(BRMs)are what is usedin immunotherapy.AlthoughBRMsnaturally;occurin the body researchhas proven thatit can now be preparedin laboratoryand is found to be justas effectiveas the naturalBRMs.

Another new mesotheliomatreatmentoptionthathas been developed is the Intensity Modulated Radiation Therapy(IMRT).IMRTis a new treatmentusedto enhance localized control of mesothelioma. In thistherapy, researchershavefound a way for radiationdoses to be administeredto the tumorwithout causingundue damage to nearby normal,healthy cells.

Treatmentat the DNA level is alsoanother important breakthroughthatresearchershavemade. In Gene Therapy,doctors will try to correct or replace the abnormal or damaged genes.The two maintypes of Gene Therapymostcommonlyusedtoday are Replacement genetherapyand knockoutgenetherapytherapy.In replacementgenetherapythe mutatedor missing genewhichcausesthe mesotheliomais replacedwhereas in knockoutgenetherapy, the generesponsible for creating the tumoris completely eliminated. Withmoreresearchbeingdone in genetherapytoday,much moreinformation regardinggenes;are beingunfoldedconstantly.As such, genetherapytreatments;holds the highest promiseof the future in the treatmentof mesothelioma.

Other formsof treatments;whichuse somecombinationsof surgery,radiationtherapy, and chemotherapy, sometimescalledmultimodality therapy, are alsocurrently beingresearched;.

Lastbut not least,Heated Intraoperative Intraperitoneal Chemotherapycombined with the use of a pemetrexed drug, brand namedAlimta,are someof the new developmentsin the treatmentof mesothelioma.

Withresearchgoingon in somemany spheresfrom Gene Therapy,Biologicals as well as combinational treatments;, the outlookfor mesotheliomatreatmentoptions;looksto be brightand expanding.

Thomas Xiao – About the Author:

Ben is an accomplished online publisher with many websites setup dealing with a variety of issues. Check out his latest site on Mesothelioma Treatment Options and also the article on Dealing With Abestos At Home

Source: http://www.articlesbase.com/human-resources-articles/mesothelioma-treatment-options-1356071.html

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Article Tags:
mesothelioma treatment options, new mesothelioma treatment, mesothelioma lung cancer

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New Mesothelioma Treatment Options

Recently, there have been a number of new mesothelioma treatments being developed. This has given victims of mesothelioma new hopes for more and better mesothelioma treatment options for this disease.

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Denver Mesothelioma Attorneys

Denver Mesothelioma Attorneys

Denver Mesothelioma Attorneys

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Denver Mesothelioma Attorneys

By: K James
Posted: Dec 31, 2009

What is Mesothelioma?

The National Cancer Institute states that, “Malignant mesothelioma, a rare form of cancer, is a disease in which malignant cells are found in the lining of the chest or abdomen.”

How do you get Mesothelioma?

Most people who develop mesothelioma have worked on jobs where they inhale asbestos particles or have been exposed to asbestos dust and fiber in other ways like on the skin.

What are some of the Signs and Symptoms of Mesothelioma?

The symptoms of mesothelioma may not appear until 20 to 50 years after exposure to asbestos. Some of the signs and symptoms include: weight loss, shortness of breath, fatigue, acute pain in the abdominal region and chest area, abdominal swelling and anemia.

What are some of the Treatments used for Mesothelioma?

Treatments include: conventional therapies, surgeries, chemotherapy, radiation therapy, immunotherapy, and or a combination of treatment and medications.

Are there Legal Issues involved in Mesothelioma?

If you or someone you love has been diagnosed with mesothelioma, you may have legal right to seek compensation from the companies responsible for your exposure to asbestos. If you wish to seek compensation for your diagnosis and the pain and suffering that comes with mesothelioma, then it is important that you consult an attorney immediately.

What should I do after being diagnosed with Mesothelioma in Denver?

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Once diagnosed with mesothelioma, and you are getting the proper care and treatment by a professional medical team, you should immediately seek legal advice and counsel from a knowledgeable mesothelioma attorney who has experience in such cases. Your mesothelioma diagnosis will require medical and legal advice, which is where a qualified Denver mesothelioma attorney can help you. A qualified Denver mesothelioma attorney will be able to tell you everything you need to know about your legal rights and the amount of compensation to expect. Mesothelioma attorneys have the expertise in settling mesothelioma cases. You deserve the best treatment both medically and legally, so seek the aid of a qualified Atlanta mesothelioma attorney as soon as possible.

Why do I need to file a Lawsuit?

Filing a mesothelioma lawsuit against your employer or big companies can be intimidating. However, these companies need to be held accountable for providing an unsafe working environment for their employees. Because of their negligence, you have to go through an enormous amount of pain and suffering.

It is not your fault that you were exposed to asbestos and it should not be your responsibility to bear the financial burden. This is a terrible disease and you should seek the compensation that you deserve. The treatment can be very expensive and can become a heavy burden on you and your loved ones during such a difficult time.
An experienced Denver mesothelioma attorney can help you get the compensation you and your family deserve. Hiring an attorney will also increase your chances of winning your lawsuit.

Is there a Statue of Limitation to file a Lawsuit?

The law imposes a statute of limitations however; it varies from state to state and Denver is no exception. This is why it is so important that you consult a mesothelioma attorney immediately, because you may only have a limited amount of time in which a lawsuit can be filed.

Where can I find a Qualified Mesothelioma Attorney in Denver?

If you live in Denver, you should consult with a Denver mesothelioma attorney who is experienced in handling such cases. Attorneys who handle mesothelioma cases represent clients who have suffered adverse health effects from exposure to asbestos either on the job or in products. Most mesothelioma attorneys have their own websites. You can do a search on the internet or ask your doctor for a referral to a mesothelioma attorney in the Denver area or ask your local bar association for recommendations.

K James – About the Author:

Denver Mesothelioma Attorneys

Source: http://www.articlesbase.com/diseases-and-conditions-articles/denver-mesothelioma-attorneys-1648474.html

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The Relative Risks of Asbestos Exposure to Workers

The Relative Risks of Asbestos Exposure to Workers

The Relative Risks of Asbestos Exposure to Workers

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The Relative Risks of Asbestos Exposure to Workers

By: Montwrobleski77
Posted: May 17, 2010

Lung cancer and mesothelioma are two deadly diseases caused by the inhalation of asbestos particles in the workplace.  Unfortunately, it can take several decades for symptoms to become present which can delay the mesothelioma diagnosis.  One interesting study that examined occupational disease is called, “Computed tomography screening for lung cancer in asbestos-exposed workers” by M.Tiitola – Lung Cancer, Volume 35, Issue 1, Pages 17-22.  Here is an excerpt: “Abstract – We conducted a computed tomography (CT) screening for lung cancer in a high-risk population. Six hundred and two workers (38–81 years, 97% smokers) with asbestos-related occupational disease were screened using spiral CT and chest radiography. The national cancer registry was checked for possible false negative cases. The screening detected 111 patients with non-calcified nodules >0.5 cm in diameter and 66 of them were referred for further hospital examination. We found five lung cancers (106 false positive cases) with a histological spectrum similar to the national, natural occurrence of the disease (two adeno, one squamous cell, one anaplastic and one metastatic carcinoma) and one peritoneal mesothelioma. Three cases were potentially operable (stage I–II).

Unfortunately there was one false negative fine-needle aspiration biopsy (FNAB) with misinterpretation of the follow-up CT scan and another patient who refused further investigations after an inadequate FNAB. In the end only one patient with adenocarcinoma underwent surgery. After 3 years of follow-up two new lung cancers were reported to the cancer registry with no evidence of tumour in the retrospective analysis of the screening CT scan. The sensitivity of CT screening was 100%. CT was capable of detecting early lung cancer in asbestos-exposed patients with a lot of confusing pulmonary and pleural pathology. Due to the high number of positive findings attention should be paid to patient compliance and the follow-up protocols and patient selection in future screening programmes.”

Another interesting study is called, “Cancer Mortality among Workers Exposed to Amphibole-free Chrysotile Asbestos” by Eiji Yano, Zhi-Ming Wang, Xiao-Rong Wang, Mian-Zheng Wang and Ya-Jia Lan – American Journal of Epidemiology Vol. 154, No. 6 : 538-543.  Here is an excerpt: “The issue of whether exposure to chrysotile asbestos alone, without contamination from amphibole asbestos, causes lung cancer and mesothelioma was investigated in a 25-year longitudinal study (1972–1996) in Chongqin, China. The study cohort comprised 515 male asbestos plant workers exposed to chrysotile only; the control cohort included 650 non-dust-exposed workers. The results of analysis in which the proportional hazards model was used indicated that mortality due to all causes, all cancers, and lung cancer was related to asbestos exposure; the relative risks, adjusted for age and smoking, were 2.9, 4.3, and 6.6, respectively.

Fiber concentrations in the raw material section and the textile section of the plant were 7.6 and 4.5 fibers/ml, respectively. Because of differences between the study and control plants, the authors also compared various sections of the asbestos plant that had different levels of dust exposure. The adjusted relative risk of lung cancer was 8.1 for workers exposed to high versus low levels of asbestos. Two cases of malignant mesothelioma, one pleural and the other peritoneal, were found in the asbestos cohort. These results suggest that heavy exposure to pure chrysotile asbestos alone, with negligible amphibole contamination, can cause lung cancer and malignant mesothelioma in exposed workers.”
 
If you found any of these excerpts interesting, please read the studies in their entirety.  We all owe a great debt to these researchers for their important work.

Montwrobleski77 – About the Author:

Monty Wrobleski is the author of this article.  For more information please click on the following links  Mesothelioma Lawyer,

Mesothelioma Lawsuit Settlements,

Asbestos Exposure

Source: http://www.articlesbase.com/cancer-articles/the-relative-risks-of-asbestos-exposure-to-workers-2389555.html

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The Excess Risk of Cancer after Asbestos Exposure

The Excess Risk of Cancer after Asbestos Exposure

The Excess Risk of Cancer after Asbestos Exposure

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The Excess Risk of Cancer after Asbestos Exposure

By: Montwrobleski77
Posted: May 20, 2010

Asbestos exposure has been known to cause cell transformation and chromosomal mutations.  One group of workers that has been extensively studied is factory employees in London.  One interesting study is called, “Mortality from all cancers of asbestos factory workers in east London 1933–80″ by G Berry, M L Newhouse, J C Wagner – Occup Environ Med 2000;57:782-785.  Here is an excerpt: “Abstract – Objective – To give the observed and expected deaths due to cancer at all separate sites in asbestos workers in east London, and to analyse these for overall effect and exposure-response trend.  METHODS – The mortality experience of a cohort of over 5000 men and women followed up for over 30 years since first exposure to asbestos has been extracted. RESULTS – There was a large excess of deaths due to cancer (537 observed, 222 expected). Most of these were due to cancer of the lung (232 observed, 77 expected) and pleural (52) and peritoneal (48) mesothelioma. The exposure-response trend for all these three causes was highly significant. There was also an excess of cancer of the colon (27 observed, 15 expected) which was significantly related to exposure. There were significant excesses of cancer of the ovary, of the liver, and of the oesophagus but with no consistent relation to exposure.

CONCLUSIONS – The excess risk of cancer after exposure to asbestos was mainly due to cancer of the lung and mesothelioma. An exposure related excess of cancer of the colon was also detected but the possibility that some of these deaths may have been peritoneal mesotheliomas could not be excluded. There was no consistent evidence of exposure related excesses at any other site.”

Another interesting study is called, “Role of Phagocytosis in Syrian Hamster Cell Transformation and Cytogenetic Effects Induced by Asbestos and Short and Long Glass Fibers” by Thomas W. Hesterberg, Charles J. Butterick, Mitsuo Oshimura, Arnold R. Brody and J. Carl Barrett – Environmental Carcinogenesis Group, Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 – Cancer Research 46, 5795-5802, November 1, 1986.  Here is an excerpt: “We have shown previously that asbestos and other mineral dusts, including glass fibers, induce cell transformation and chromosomal mutations in Syrian hamster embryo cells in culture. In the present study, we observed that both asbestos and glass fibers were phagocytized by these cells and accumulated in the perinuclear region of the cytoplasm. In order to understand the mechanism of fiber length-dependent cellular effects, we examined the phagocytosis and intracellular distribution of glass fibers of differing lengths in cells at various times after treatment. Glass fiber length was decreased by milling with a mortar and pestle. Cells treated with an equal dose of milled glass fibers (on a weight per surface area basis) were exposed to 7-fold more fibers since milling of glass fibers resulted in a 7-fold decrease in length with little change in diameter.

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The Relative Risks of Asbestos Exposure to Workers
Toxic Effects of Asbestos Exposure and Disease Causation

However, cells exposed to milled glass fibers phagocytized a similar number of fibers as cells exposed to an equal mass of unmilled glass fibers, indicating that milled fibers were less readily phagocytized. In cells treated with either unmilled or milled glass fibers, the length of the intracellular fibers was more than 2-fold greater than the length of the fibers on the surface, suggesting that cells selectively internalized longer fibers. Fiber length, however, did not appear to affect the migration of intracellular fibers to the perinuclear region of the cytoplasm. Even though cells treated with milled glass fibers contained a similar number of fibers as those treated with unmilled glass fibers, the resulting cytotoxicity, transformation frequency, and frequency of micronuclei were greatly reduced in the cultures treated with milled glass fibers. Thus, fiber length appears to affect the phagocytosis of fibers as well as the ability of intracellular fibers to induce cytogenetic damage and the resultant transformation.”

Another interesting study is called, “Airway function in lifetime-nonsmoking older asbestos workers” by R. Bégin, A. Cantin, Y. Berthiaume, R. Boileau, S. Péloquin, S. Massé – The American Journal of Medicine, Volume 75, Issue 4, Pages 631-638.  Here is an excerpt: “Abstract – Previous studies of lung function in asbestos workers have documented airflow limitation in many of the workers, but the specific influence of asbestos exposure could not be clearly differentiated from the effects of the cigarette smoking habit. In this study, airway function was evaluated in lifetime-nonsmoking, long-term workers of the mines and mills of Québec. The 17 asbestos workers in this study had worked for an average of 28 years in the mines and mills of the local asbestos industry and did not have any other respiratory industrial dust exposure. They did not have a history of previous pulmonary disease and did not meet the usual diagnostic criteria for chronic bronchitis, emphysema, or asthma. Seven of the workers met the diagnostic criteria for asbestosis and 10 workers did not. The latter group of workers did not differ from a matched control group except in terms of a higher isoflow volume (p < 0.05). The workers with asbestosis, however, had a restrictive pattern of lung function, increased isoflow volume, and Increased upstream resistance at low lung volumes (p < 0.01). Lung biopsy in three of the patients with the disease demonstrated peribronchiolar alveolitls and fibrosis with obliteration and narrowing of the small airways.

These data on lifetime-nonsmoking, long-term asbestos workers provide further evidence of small airway obstruction associated with asbestos exposure and independent of the smoking habit. This airflow limitation was observed predominantly in workers with a restrictive pattern of lung function associated with peribronchiolar alveolltis. The lifetime-nonsmoking asbestos workers without restrictive patterns of lung function had minimal dysfunction of the peripheral airways.”

If you found any of these excerpts, please read them in their entirety.  We all owe a debt of gratitude to these researchers.

Montwrobleski77 – About the Author:

Monty Wrobleski is the author of this article.  For more information please click on the following links  Mesothelioma Lawyer, Mesothelioma Lawsuit Settlements, BP Oil Spill Class Action Lawsuit

Source: http://www.articlesbase.com/cancer-articles/the-excess-risk-of-cancer-after-asbestos-exposure-2416028.html

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Mesothelioma Latest – New Treatments for Those Afflicted With Pleural Mesothelioma

Mesothelioma Latest – New Treatments for Those Afflicted With Pleural Mesothelioma

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Mesothelioma Latest – New Treatments for Those Afflicted With Pleural Mesothelioma

By: Dr. Joseph Stephens
Posted: Oct 09, 2008

Pleural Mesothelioma is the most prevalent form of the various aggressive lung cancers and this cancer invades the lung cavities. ‘Pleura’ is the sac that houses the lungs within a thin membrane called mesothelium. This mesothelium secretes fluid and assists the lungs to contract and expand during breathing.

Pleural mesothelioma is the <a rel=”nofollow” onclick=”javascript:_gaq.push(['_trackPageview', '/outgoing/article_exit_link/595693']);” href=”http://mesotheliomastraight.net/asbestos”>cancer of the mesothelium</a> of the lung cavities and it is associated with individuals who live in surroundings where asbestos-related dust is major air pollutant. Prolonged inhalation of the air-borne asbestos-related particles leads to inflammation of the lungs and eventually the asbestos particles and fibers get settled on the lung surfaces and thereby making the tissues carcinogenic.

The cancer cells remains dormant for long, but symptoms slowly begin with a normal chest pain coupled with some warning signals such as:

* Difficulty in breathing and shortness of breath
* Loss of appetite and weight loss
* Excessive coughing and wheezing
* Tendency to vomit often

Read more articles
3 Types of Mesothelioma: Which is Worse?
Mesothelioma’s Deadly Causes and Solutions

Tests and Diagnoses:

It is extremely difficult to diagnose pleural mesothelioma as it is often confused with common illnesses as cold and/or flu, whooping cough or pneumonia due to almost similar symptoms. However, thanks to many diagnostic procedures the disease can be confirmed.

Chest x-ray and MRI: These are painless imaging studies and along with CT scan and ultrasound the radiologist gets a detailed picture of the lungs that reveal pleural effusion.

Biopsy: A radiological scan is followed by a needle biopsy (also called an aspiration biopsy) to confirm the cancer cells by taking out fluid from the lungs.

It is then a pleuroscopy and thoracotomy done to confirm the presence of pleural mesothelioma.

<a rel=”nofollow” onclick=”javascript:_gaq.push(['_trackPageview', '/outgoing/article_exit_link/595693']);” href=”http://mesotheliomastraight.net/asbestos”>Treatment Methods:</a>

Complete cure for this silent killer disease is still a far cry. An expert treats with multi-modality approach and it is most likely to be a palliative form of treatment. The approach includes combination of surgery, radiation, photodynamic therapy and systemic chemotherapy with cancer drugs (often times Cisplatin and gemcitabine).

Some of the advancements in the field of pleural mesothelioma therapy include:

Administering pemetrexed, an antimetabolite along with Cisplatin and this adjuvant therapy is found to give a higher survival rate than using Cisplatin alone.

Using the dynamics of light is also used as a principle to kill carcinogenic cells. However, this can be a method when mesothelioma is in the early stages.

Immunotherapy is another approach that aims to enhance the body immune system but as of now still being researched to use as an alternative to treat a pleural mesothelioma patient.

Brachytherapy is another newborn approach, and it is a kind of radiation therapy applied from within the body as opposed to application from outside. This helps to prevent damage of healthy cells due to exposure to high radiation.

Dr. Joseph Stephens – About the Author:

I am a health care professional who writes about mesothelioma at Mesothelioma Striaght. My latest post is here: Mesothelioma Details and Findings.

Source: http://www.articlesbase.com/cancer-articles/mesothelioma-latest-new-treatments-for-those-afflicted-with-pleural-mesothelioma-595693.html

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Mesothelioma’s Deadly Causes and Solutions

Mesothelioma is a form of cancer caused due to exposure to asbestos. Mesothelioma mainly affects the mesothelium which is a protective lining covering all internal organs of the body. Mostly, it originates in the pleura, which is the between the outer part of the lungs & the chest cavity. Mesothelioma may also attack in or the lining of abdominal cavity (peritoneum) or the sac which surrounds heart (that is, pericardium).

What does this all mean? Read to find out more.

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Pericardial Mesothelioma: Most Deadly Case?

Pericardial mesothelioma is the cancer that affects the pericardium of the heart. The disease is mostly associated with those that are exposed to asbestos-related environment. It is not known exactly how the asbestos particles get embedded on the membranous lining of heart.

Find out more about it here.

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Mesothelioma and Surgical Tumors Explored

Mesothelioma and Surgical Tumors Explored

Mesothelioma and Surgical Tumors Explored

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Mesothelioma and Surgical Tumors Explored

By: Montwrobleski77
Posted: Oct 05, 2010

An interesting study is called, “Ultrastructural comparison of an adenomatoid tumor, lymphangioma, hemangioma, and Mesothelioma” by Joseph B. Marcus MD,†, Joseph A. Lynn MD, – Cancer Volume 25, Issue 1, pages 171–175, January 1970.  Here is an exerpt: “Abstract – An electron microscopic study was made comparing an adenomatoid tumor with a hemangioma, lymphangioma, and 2 mesotheliomas in an attempt to elucidate the cell of origin of the adenomatoid tumor. Using ultrastructural criteria, one could say that neither the hemangioma or lymphangioma were structurally related to the adenomatoid tumor. It was not possible to morphologically distinguish between the cells of the mesothelioma and that of the adenomatoid tumor.”

Another interesting study is called, “Phase II trial of high-dose cisplatin in patients with malignant mesothelioma.” By Mintzer DM, Kelsen D, Frimmer D, Heelan R, Gralla R. –
Cancer Treat Rep. 1985 Jun;69(6):711-2.  Here is an excerpt: “Abstract – Twenty-five patients with advanced malignant mesothelioma were treated in a phase II trial with high-dose cisplatin (DDP). All patients had measurable or evaluable disease. Seven patients had received prior chemotherapy. DDP (120 mg/m2) with mannitol and prehydration was given every 4 weeks for two doses and then every 6 weeks. Of 24 patients evaluable for response, three had partial responses (3, 3+, and 9 months; response rate, 13%; 95% confidence limits, 4%-31%) and one had minor response. All responses occurred in previously untreated patients. High-dose DDP has modest activity in malignant mesothelioma.”

To determine whether mesothelin can assist in discriminating epithelioid mesotheliomas from lung adenocarcinomas or from other carcinomas metastatic to the serosal membranes, 55 mesotheliomas (44 epithelioid, 3 biphasic, and 8 sarcomatoid), 48 carcinomas of the lung (31 adenocarcinomas, 17 squamous carcinomas), and 86 nonpulmonary adenocarcinomas (14 ovary, 5 peritoneum, 9 endometrium, 11 pancreas, 4 stomach, 16 colon, 12 breast, 9 kidney, 4 thyroid, and 2 prostate) were investigated for mesothelin expression using the recently available 5B2 anti-mesothelin monoclonal antibody.

Another interesting study is called, “Efficacy of cisplatin-based intraperitoneal chemotherapy as treatment of malignant peritoneal Mesothelioma” by Maurie Markman and David Kelsen – Journal of Cancer Research and Clinical Oncology – Volume 118, Number 7, 547-550.  Here is an excerpt: “Abstract – In an effort to examine the potential clinical utility of intraperitoneal (i.p.) therapy in the management of patients with malignant peritoneal mesothelioma, 19 individuals with this disease were treated with a cisplatinbased i.p. treatment regimen. All but 1 patient also received i.p. mitomycin. The treatment was generally well tolerated, although a maximum of only four or five courses of cisplatin (100 mg/m2 every 28 days) and mitomycin (5–10 mg/treatment given 7 days after each i.p. cisplatin administration) could be administered, the treatment principally being stopped because of disease progression or catheter failure. Of 15 patients with malignant ascites, 7 (47%) experienced control of fluid reaccumulation ranging from 2 months to 73+ months (median 8 months). While the median survival for the 19 patients was only 9 months, 4 (21%) patients survived for more than 3 years from the initiation of therapy, and 2 patients are currently alive and clinically disease-free more than 5 years from the start of the i.p. treatment program. We conclude that a subset of patients with peritoneal mesothelioma, principally those with small-volume residual disease following surgical tumor debulking, can benefit from a cisplatin-based i.p. treatment strategy with control of ascites and prolonged disease-free survival.”

We all owe a debt of gratitude to these fine researchers.  If you found any of these excerpts interesting, please read the studies in their entirety.

Montwrobleski77 – About the Author:

Monty Wrobleski is the author of this article.  For more information please click on the following links

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Source: http://www.articlesbase.com/cancer-articles/mesothelioma-and-surgical-tumors-explored-3408201.html

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Handling Mesothelioma this Recession

Handling Mesothelioma this Recession

Handling Mesothelioma this Recession

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Handling Mesothelioma this Recession

By: Chris M. Alexander
Posted: Sep 09, 2009

Everyone is dealing with this terrible recession that is going on in the US. It affects homeowners, renters, single people and families alike. The government has been taking necessary steps to manage this recession by cutting taxes and expenses on programs. It also increased its spending to create new jobs for the unemployed and improve the crippled manufacturing and services sectors. Unfortunately, being ill during this time is not an easy thing to deal with, especially when the disease is Mesothelioma. The prognosis and survival rates are incredible poor and the research on treatments is sometimes lacking in funding, even more so in the time of recession.

Recession and Mesothelioma

The effects of recession are being seen in many aspects of life, including people suffering from Mesothelioma. It is known fact that people are likely to contract malignant Mesothelioma, a rare form of cancer, if they are exposed to asbestos. Thousands of Mesothelioma cases are diagnosed in the United States due to occupational or household exposure to asbestos because tiny particles of the fibrous mineral were widely used in a number of industries. In addition, family members of employees were regularly exposed to asbestos as the people working in these industries carried them into their homes on their clothing, shoes, skin and hair.

Similar to all areas of healthcare, Mesothelioma research and treatment need to be handled in a different manner during the period of recession. First and foremost, people suffering from Mesothelioma and interested in filing lawsuits against the company where they were exposed to asbestos need to think realistically. It is important to analyze the amount they can receive as compensation from these companies. They need to talk everything over with a capable attorney who has handled similar cases, especially during periods of recession.

Effects of Recession on Funding Companies

Funding companies, like The Asbestos Injuries Compensation Fund, have been affected by the recession. They have declared that they will not able provide funds to victims of asbestos-related diseases, like Mesothelioma, due to the current recession. The .5 billion fund they were able to create solely through the James Hardie building materials firm in 2006 now has a deficit of about .5 million for its compensation fund payouts. This deficit is predominantly due to the decline in the housing market.

Due to the recession, the funding company made the decision to pay victims in installments rather than through lump sum payments which were the norm. To tackle the problems related to recession for Mesothelioma patients, they are requesting additional funding from the government. They believe that the option of payment through installments is not feasible as the disease is diagnosed at the later stages and at times those suffering from Mesothelioma do not typically live to see the full payout of their compensation. Apart from this, their other regular expenditures like medical bills and taking care of their family will be difficult to handle through this method of compensation. It will be very interesting to find out just how willing the government will be to help people suffering due to employer negligence.

Chris M. Alexander – About the Author:

http://mesoblog.org/blog/mesothelioma-recession/

Source: http://www.articlesbase.com/diseases-and-conditions-articles/handling-mesothelioma-this-recession-1211843.html

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Learn more about the treatment of malaria

Travelling is quite easy but taking care of your health is not. Public health has started becoming more and more prone to health conditions as you travel around the world. Malaria and traveller’s diarrhoea are common infections that you can contract. Read further to learn more on treatment of malaria.

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Mesothelioma Alert – Hidden Health Hazards Exposed by NBS Station, Kansas City

Mesothelioma Alert – Hidden Health Hazards Exposed by NBS Station, Kansas City

Mesothelioma Alert – Hidden Health Hazards Exposed by NBS Station, Kansas City

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Mesothelioma Alert – Hidden Health Hazards Exposed by NBS Station, Kansas City

By: Chris M. Alexander
Posted: Oct 05, 2009

Do you what causes Mesothelioma? Mesothelioma is a dreaded disease caused by asbestiform, or more popularly known asbestos. This disease is a slow killer. The disease develops atleast 30 to 40 years after it has been contracted.

Mesothelioma Health Hazards

Close to 75 to 80% of the Mesothelioma cases state the asbestos exposure as the primary reason for contracting the disease. Do you know what it is to lead a happy life for 50 to 60 years and suddenly find yourself suffering from cancer for some reason that happened 50 years ago? In simple words that is Mesothelioma Cancer.

Asbestos Exposure and Mesothelioma

The asbestos particles inhaled stay in your body for decades together and slowly begin damaging your body and make you realize something is wrong with your health only during the advanced stages of mesothelioma. Unfortunately, in most of such cases, the time period is so long that the person suffering would have even forgotten the happening of such an event of asbestos exposure.

Read more articles
Life Expectancy of Mesothelioma Patients
Mesothelioma: a Cancer Which is Caused Due to Exposure to Asbestos
Mesothelioma – How To Manage Malignant Mesothelioma Cancer
Newyork Mesothelioma Lawyer Reveals Her Secret On Mesothelioma, Personal Injury, Asbestos Cases:

In certain other cases the person might not even know that he was exposed to asbestos. According to Environment Protection Agency there is as such no safe exposure limit for asbestos particles. Prevention is always better; hence one should wear proper shielding before venturing into any asbestos exposure activity.

Mesothelioma Hidden Health Hazards exposed by NBS Station, Kansas City

Out of the many efforts taken by organizations to create awareness about asbestos exposure and the resultant contraction of mesothelioma, the NBS Station in Kansas City came up with a documentary video on the ill effects of mesothelioma and risk of asbestos exposure. The video has been named as “Hidden Hazard Missed by Contractors”. The story is all about the dangers involved in removing an old popcorn ceiling, which is said to have tiny asbestos particles in it and the ill effects of inhaling such asbestos particles.

In recent times the case of second hand exposure to asbestos is on the rise. The households namely wife, children and siblings are highly exposed to the danger of asbestos exposure. Though they are not directly subjected to asbestos exposure, the asbestos particles carried in the clothes of the individual visiting such places poses a serious health hazard.

In short, it is high time to be careful about the disease and the consequent threats in human life.

Chris M. Alexander – About the Author:

The NBS Station in Kansas City came up with a documentary video on the ill effects of mesothelioma and risk of asbestos exposure.

Source: http://www.articlesbase.com/diseases-and-conditions-articles/mesothelioma-alert-hidden-health-hazards-exposed-by-nbs-station-kansas-city-1302882.html

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Learn more about the treatment of malaria

Travelling is quite easy but taking care of your health is not. Public health has started becoming more and more prone to health conditions as you travel around the world. Malaria and traveller’s diarrhoea are common infections that you can contract. Read further to learn more on treatment of malaria.

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Upper Lobe Tumors and Asbestos Exposure

Upper Lobe Tumors and Asbestos Exposure

Upper Lobe Tumors and Asbestos Exposure

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Upper Lobe Tumors and Asbestos Exposure

By: Montwrobleski77
Posted: Aug 21, 2010

Over 2,000 new cases of Mesothelioma are diagnosed each year in the United States (making up about 3 % of all cancer diagnoses).  The more research that is dedicated to finding a cure for this disease, the better.  One interesting study is called, “A Meta-Analysis of Colorectal Cancer and Asbestos Exposure” by David M. Horna, David H. Garabrant, and Brenda W. Gillespie -  American Journal of Epidemiology Vol. 139, No. 12: 1210-1222.  Here is an excerpt: “A meta-analysis of the relation between asbestos exposure and colorectal cancer mortality was conducted, using published reports of 20 asbestos-exposed cohorts. Summary standardized mortality ratios (SMRs) for colorectal cancer were examined in relation to asbestos type and estimates of dust exposure (as direct estimators of asbestos exposure) and in relation to lung cancer SMR and the proportion of all deaths due to mesothelioma (as proxy estimators of asbestos exposure). An elevated summary SMR was observed in cohorts exposed to amphibole asbestos (summary SMR = 1.47; 95% confidence interval (Cl) 1.09–2.00), but not in cohorts exposed to serpentine asbestos (summary SMR = 1.04; 95% Cl 0.81–1.33) or in cohorts exposed to both serpentine and amphibole asbestos (summary SMR = 1.03; 95% Cl 0.74–1.42). Cohorts having a lung cancer SMR greater than 2.00 had a summary SMR of 1.51 (95% Cl 1.29–1.76), and cohorts in which more than 1 % of all deaths were attributed to mesothelioma had a summary SMR of 1.24 (95% Cl 0.94–1.64), After stratifying the cohorts based on mortality due to all cancers excluding those known or suspected to be associated with asbestos exposure, lung cancer mortality was not clearly associated with colorectal cancer mortality, suggesting that the crude association between these factors may be due to misdiagnosis of lung cancer as other types of cancer in the reported causes of death. These results suggest that exposure to amphibole asbestos may be associated with colorectal cancer, but these findings may reflect an artifact of miscertification of cause of death. The results also suggest that serpentine asbestos is not associated with colorectal cancer.”

A second study is called, “Association of Cigarette Smoking and Asbestos Exposure with Location and Histology of Lung Cancer” by BURTON W. LEE, JOHN C. WAIN, KARL T. KELSEY, JOHN K. WIENCKE, and DAVID C. CHRISTIANI – Am. J. Respir. Crit. Care Med., Volume 157, Number 3, March 1998, 748-755.  Here is an excerpt: “Prior studies have suggested that lung cancers that arise in association with cigarette smoking favor an upper-lobe location while those associated with asbestos exposure favor a lower-lobe location. An excess of adenocarcinomas has also been reported among cases not exposed to cigarette smoke as well as among those exposed to asbestos. However, these studies typically have not adjusted adequately for potential confounders such as the patient’s age, sex, race, or family history of cancer. To better examine the effects of cigarette smoking and asbestos exposure on location and histology of lung cancer, we analyzed data from a large case-control study that included 456 patients with stage I or II lung cancer. Patients with upper-lobe tumors tended to have had more exposure to tobacco as assessed by pack-years smoked (54.7 versus 46.2, p = 0.07) and less time since quitting smoking (3.0 versus 5.5 yr, p = 0.05). In contrast to some prior reports, asbestos exposure was also associated with an upper-lobe location of tumor. Among those with upper-lobe tumors, 14.6% had a history of significant asbestos exposure compared with 5.4% of those with lower-lobe tumors (p < 0.01). The relationship between asbestos exposure and upper-lobe location of tumor was also statistically significant whether stratified by smoking or analyzed by multivariable logistic regression modeling. Adenocarcinomas were more likely among those with less exposure to cigarette smoke based on fewer pack-years smoked (41.5 versus 61.8, p = 0.0001) and more time since quitting smoking (5.0 versus 3.0 yr, p = 0.02). The proportion of patients with significant exposure to asbestos was lower among those with adenocarcinomas but was not statistically significant (9.5 versus 15.3%, p = 0.09). In multivariable logistic regression analysis, longer time since smoking exposure remained a significant predictor of adenocarcinomas (p < 0.02), but history of asbestos exposure did not predict tumor histology. Thus, in patients with lung cancer, both cigarette smoking and asbestos exposure histories favor an upper-lobe location of tumor. Longer time since smoking exposure favors adenocarcinomas, but the history of asbestos exposure does not appear to influence the tumor histology.”

If you found any of these studies interesting, please read them in their entirety.  We all owe a great deal of thanks to the people who are researching these important issues.

Montwrobleski77 – About the Author:

Monty Wrobleski is the author of this article, for more information please visit the following links Nephrogenic Systemic Fibrosis,

Nephrogenic Systemic Fibrosis Lawyer,

Mesothelioma Attorneys

Source: http://www.articlesbase.com/cancer-articles/upper-lobe-tumors-and-asbestos-exposure-3095690.html

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Mesothelioma and the Modalities of Aggressive Surgery Radiotherapy and Chemotherapy

Mesothelioma and the Modalities of Aggressive Surgery Radiotherapy and Chemotherapy

Mesothelioma and the Modalities of Aggressive Surgery Radiotherapy and Chemotherapy

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Mesothelioma and the Modalities of Aggressive Surgery Radiotherapy and Chemotherapy

By: Montwrobleski77
Posted: Dec 22, 2010

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Another study is called, “The palliative benefits of MVP (mitomycin C, vinblastine and cisplatin) chemotherapy in patients with malignant Mesothelioma” by E. Andreopoulou, P. J. Ross, M. E. R. O’Brien*, H. E. R. Ford, K. Priest, T. Eisen, A. Norton, S. Ashley and I. E. Smith – Oxford Journals Medicine Annals of OncologyVolume15, Issue9Pp. 1406-1412.  Here is an excerpt: “Abstract – Background: With the rising incidence of malignant mesothelioma (MM), it is important to optimise treatment to control symptoms, maintain quality of life and, if possible, prolong life. We have analysed prospectively collected data to evaluate a frequently used palliative chemotherapy regimen. Patients and methods: Between October 1986 and May 2002 all patients with inoperable pleural mesothelioma were considered for treatment with MVP (mitomycin C 8 mg/m2 every 6 weeks, vinblastine 6 mg/m2 every 3 weeks and cisplatin 50 mg/m2 every 3 weeks) chemotherapy. Symptoms were assessed by physician assessment at baseline and after each cycle of chemotherapy.

Results: One hundred and fifty patients were treated with MVP for mesothelioma. Forty-three per cent had a performance status (PS) 2 or worse. The response rate was 15.3%, with 68.6% having stable disease. Sixty-nine per cent reported an improvement in symptoms; in particular there were good responses for pain (71%), cough (62%) and dyspnoea (50%). The most common grade 3/4 toxicity was neutropenia (22%). Median overall survival was 7 months, with 1-year survival 31% and 2-year survival 11%. Median survival for patients with PS 0/1 was 10 months, and was 6 months for patients with PS 2/3. Poor prognostic factors in univariate analysis included poor PS, weight loss, mixed or sarcomatoid histology, low haemoglobin and high white blood cell count. Excluding pathological subtype, the prognostic significance of poor PS and weight loss were retained in multivariate analysis. Conclusions: Palliation of symptoms in MM is achievable with current cisplatin-based treatments.

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One interesting study is called, “Effects of glycosaminoglycans on proliferation of epithelial and fibroblast human malignant mesothelioma cells: a structure–function relationship” by Christopher Potten, Zbigniew Darzynkiewicz, Kohsuke Sasaki, A. Syrokou, G. Tzanakakis, T. Tsegenidis, A. Hjerpe, N. K. Karamanos – Cell Proliferation Volume 32, Issue 2-3, pages 85–99, April 1999.  Here is an excerpt: “Abstract. Proteoglycans interact with other effective macromolecules regulating a variety of cellular events via their glycosaminoglycan (GAG) chains. The effects of all known glycosaminoglycans (GAGs) produced by normal cells and tissues on the proliferation of two human malignant mesothelioma cell lines, one with fibroblast-like morphology and the other with epithelial differentiation – both able to produce hyaluronan (HA), galactosaminoglycans (GalAGs) and heparan sulphate (HS) containing proteoglycans – have been studied. Cell proliferation was assessed by measuring [3H]thymidine incorporation and cell number. GalAGs, i.e. chondroitin sulphates (CSs) and dermatan sulphate (DS), strongly stimulate the proliferation of fibroblast-like cells in a dose-dependent manner (170–250% at 100 μg/ml), independently of their sulphation pattern. In epithelial cells, however, only DS stimulates cell proliferation. The effects of CSs on proliferation of epithelial cells are not depended on their sulphation pattern. Thus, CSs either with -[GlcA-GalNAc-(-6-O-SO3−)]- or -[GlcA-GalNAc-(-4-O-SO3−]- as the commonest unit, had no significant effect. l-Iduronic acid (IdoA)-rich heparin and fast-moving HS (fm-HS), a HS fraction with a heparin-like structure, had significant antiproliferative effects on mesothelioma cells of both types (30–70% at 1.0 μg/ml and 85–90% at 100 μg/ml, respectively). GlcA-rich HS, however, had no significant effects. HA inhibits only the proliferation of fibroblast-like cells by 25% at 50 and 100 μg/ml. Keratan sulphate suppresses cell proliferation (10–30%) in both cell lines. In the view of these findings, a structure–function relationship of GAGs on cell proliferation of the two human malignant mesothelioma cell lines is discussed. Other factors, such as chain conformation and geometry, as well as interactions of growth factors with GAGs, possibly involved in the regulation of cell proliferation, are also discussed.”

Another study is called, “Ectopic thymoma mimicking diffuse pleural mesothelioma: A case report” – Volume 29, Issue 4, Pages 409-410 (April 1998) by Hiroaki Fushimi, MD, Yoshiro Tanio, MD, Kiyoshi Kotoh, MD.  Here is an excerpt: “Abstract – A case of ectopic thymoma of the pleura with a particular growth pattern mimicking diffuse pleural mesothelioma is reported.  Diagnostic imaging showed that the pleural tumor encased the entire left lung. The specimen biopsied from the tumor was composed of lymphocytes and epithelial cells, consistent with the mixed type of thymoma. The autopsy found no evidence of a mediastinal tumor. An involuted thymus was found in the parietal pleural tissue adhered to the apex of the left lung. The thymoma was thought to originate from the ectopic thymic tissue in the parietal pleura, as a lesion independent from the primary mediastinal thymoma, and spread along the pleura like diffuse mesothelioma.

Conclusion: The results of our study have shown that fatal pulmonary toxicities were associated with radiation to the contralateral lung. V20 was the only independent determinant for risk of PRD or non–cancer-related death. The mean V20 of the non-PRD patients was considerably lower than that accepted during standard thoracic radiotherapy, implying that the V20 should be kept as low as possible after extrapleural pneumonectomy.

 If you found any of these excerpts interesting, please read the studies in their entirety.

Montwrobleski77 – About the Author:

Monty Wrobleski is the author of this article.  For more information please click on the following links

Mesothelioma Lawyer

Mesothelioma Lawyer

Mesothelioma Lawyer

Source: http://www.articlesbase.com/cancer-articles/mesothelioma-and-the-modalities-of-aggressive-surgery-radiotherapy-and-chemotherapy-3897904.html

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